When administered ftorafur rapidly absorbed from the gastrointestinal tract and found in the blood of at least 24 hours after a single administration. The maximum drug concentration in the blood is achieved within 4-6 hours after ingestion. Bioavailability is almost complete. It has high lipophilicity , while remaining water-soluble compound. High lipophilicity ensures rapid passage through biological membranes, the distribution in the body and penetrate the blood-brain barrier. It is metabolized in the liver to produce metabolites, among which the central place is occupied by a pharmacologically active 5-fluorouracil. Bioactivation clen cycle is carried out not only in the liver, but may be of a local character and in tumor tissues contain clenbuterol reviews high cytosolic hydrolytic enzymes.
INDICATIONS Cancer of the colon and rectum, stomach, breast; atopic dermatitis, cutaneous lymphoma.
CONTRAINDICATIONS Hypersensitivity to the drug. End-stage disease, acute profuse bleeding, severe liver and / or kidney disease, leukopenia , thrombocytopenia and anemia , pregnancy and lactation.
WITH CARE Patients with impaired functions of blood, liver and kidneys, glucose metabolism, gastric ulcer and duodenal ulcer primobolan depot, a tendency to bleeding, infections. Is not clear for kids safety of the drug.
DOSAGE AND ADMINISTRATION inside. Ftorafura daily dose clen cycle in 2.4 reception but not more than 2 g / day. Heading dose – 30-40, the interval between courses of 4 weeks. Ftorafura dose may be reduced in elderly patients and at a late stage of the disease.
Side effect From hemopoiesis system : a leukopenia, thrombocytopenia, anemia. On the part of the digestive system : nausea, vomiting, anorexia, abdominal pain, diarrhea; rarely – stomatitis, pharyngitis, esophagitis, ulceration of the gastrointestinal mucosa, bleeding from the gastrointestinal tract, liver dysfunction, acute hepatitis, acute pancreatitis. From the nervous system : dizziness, confusion, drowsiness, ataxia, euphoria. On the part of the cardiovascular system : false angina, angina pectoris, myocardial ischemia, myocardial infarction. On the part of the organs of vision : diplopia, lacrimation, fibrosis of the lacrimal ducts. On the part of the skin and skin appendages : alopecia, skin disorder regeneration nails. Others : allergic reactions (including anaphylactic shock ), renal failure, dehydration, leykoentsefalita symptoms, interstitial pneumonia, loss of sense of smell.
Overdose Symptoms :. Increase in toxic effects on the gastrointestinal tract, central nervous system and inhibition of hematopoiesis Treatment : control hematopoiesis function for at least 4 weeks, if necessary spend symptomatic therapy. The specific antidote what is winstrol to tegafur are not known.
Interaction with other drugs With simultaneous application clen cycle ftorafura and phenytoin may increase the action of the latter. The drug increases the efficacy of other chemotherapeutic agents and radiation therapy (also enhanced and side effects). Inhibitors of microsomal oxidation in the liver increases the toxicity.
Cautions In appointing ftorafura should pay special attention to patients with impaired function of blood, liver and kidneys, glucose metabolism, gastric ulcer and duodenal ulcer, a tendency to bleeding, infections. Regularly should monitor blood picture, liver function and kidney. Prolonged use of the drug is enhanced its side effects. It will be appreciated that the drug inhibits the reproductive function of the patient. Children safety of the drug is not clear. Dizziness, nausea and vomiting decrease at a daily dose fractionation. With the development of serious side effects, you must discontinue use of the drug. bodybuilding protein shake dnp dinitrophenol bodybuilding.com promocode