From the digestive system: nausea, vomiting, diarrhea, abdominal pain, stomatitis, glossitis, short-term discoloration of the teeth and clenbuterol dosage tongue, pancreatitis, pseudomembranous enterocolitis, cholestatic jaundice, hepatitis. Liver function abnormalities can be severe, but it is usually reversible. Very rarely, there have been cases of hepatic failure and death largely on the background of severe concomitant diseases and / or concomitant medication.
On the part of the central and peripheral nervous system: headache, vertigo, paresthesia, drowsiness, hallucinations, seizures, psychosis, dizziness, confusion, anxiety, insomnia, “nightmarish” dream, depersonalization, disorientation.
From the side of blood and lymphatic system: leukopenia, thrombocytopenia.
From the senses: taste alteration (dysgeusia), sense of smell, ringing in the ears, hearing loss, short passing after discontinuation of the drug.
Cardio-vascular system: prolongation of interval ventricular tachycardia type “pirouette» .
The respiratory system: dyspnea.
From the musculoskeletal system: arthralgia, myalgia.
With the genitourinary system: interstitial nephritis, renal failure.
Allergic reactions: skin sp, hives, itching, swelling of the face, anaphylactic shock, Stevens – Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), angioneurotic angioedema.
Laboratory indicators: increase in activity of “liver” transaminases and alkaline phosphatase, increased serum levels of bilirubin, creatinine, uric acid, prolonged prothrombin time, thrombocytopenia (unusual bleeding, bleeding), leukopenia, neutropenia, hypoglycemia in patients treated with hypoglycemic drugs.
Other: long-term use may develop cases of superinfection, candidiasis, microbial resistance (pseudomembranous colitis, candidiasis of the oral cavity).
Symptoms: vomiting, abdominal pain, headache and confusion. Treatment: gastric lavage, symptomatic therapy.
Interaction with other drugs:
Clarithromycin is metabolized clenbuterol dosage in the liver, where it can inhibit the action of the complex enzyme cytochrome P-450. In simultaneous treatment with clarithromycin and other drugs metabolized by this system, the concentration of the last may increase and cause side effects. Therefore, terfenadine, cisapride, pimozide or astemizole should not be used during treatment with clarithromycin because of the threat of life-threatening arrhythmias. It is recommended to measure the concentration of theophylline, carbamazepine, digoxin, lovastatin, simvastatin, triazrlama, midazolam, phenytoin, cyclosporine, disopyramide, rifabutin, tacrolimus, itraconazole and ergot alkaloids in serum when administered concurrently with clarithromycin, as it increases the risk of the possibility of side effects of the latter. prothrombin time in patients should be monitored periodically receiving clarithromycin concurrently with warfarin or other anticoagulants peroralnymi.
Co-administration of clarithromycin and zidovudine reduces the absorption of zidovudine (between the use of drugs should be an interval of at least 4 hours). Simultaneous administration of ritonavir, clarithromycin, and leads to a significant increase in the levels of clarithromycin and a significant reduction in serum levels of its metabolite 14-hydroxyclarithromycin serum. Perhaps the development of cross-resistance between clarithromycin, lincomycin and clindamycin.
Among macrolide antibiotics there is cross-resistance.
Adjusting the dose is not necessary for patients with impaired hepatic function moderate if renal function is correct.
However, the dose should be reduced in patients with impaired renal function, severe. In the presence of chronic liver disease is necessary to carry out regular monitoring of serum enzymes.
When concomitant administration of drugs metabolized by the liver, it is recommended to measure their serum concentration.
In the case of a joint appointment with warfarin or other indirect anticoagulants is necessary to monitor the prothrombin time.
Not currently available enough experience regarding the efficacy and safety of clarithromycin in the treatment of children under 6 months.
treatment with antibiotics alters the normal flora of the intestine, so it can be seen superinfection caused by resistant organisms. In case of severe, persistent diarrhea which may indicate pseudomembranous colitis should stop taking the drug and consult a physician.
In the 125 mg granules for clenbuterol dosage suspension for oral administration,sucrose, so the drug is not It recommended for children with congenital fructose intolerance, glucose malabsorption syndromes / galactose or a deficiency of the enzyme sucrase-isomaltase.
Effects on ability to drive a car or other mechanical means: the drug has no effect on psychomotor speed patient reactions when driving or operating machinery.
Composition Tablets, film-coated, 250 mg and 500 mg. For seven tablets per blister. 2 blisters in a cardboard pack together with instructions for use.
Granules for suspension for oral administration, 125 mg / 5 ml. 25 g of granules in dark glass bottles of 100 ml capacity, with a circular mark on 60 ml of the final suspension, sealed with a plastic stopper with divider liquid and plastic cover with the control of the first opening. 1 bottle complete with a dosing syringe and instructions for use in paper cartons.