Liver: the liver from the reaction can vary from asymptomatic dysfunction of liver cells, detectable only by laboratory methods to severe liver dysfunction, manifested by jaundice. These side effects usually do not occur when receiving pyrazinamide in doses not to exceed 25 mg / kg per day; the addition of pyrazinamide to isoniazid does not lead to an increase in the overall frequency of liver toxicity.
From the gastrointestinal tract: may clenbuterol cycle experience decreased appetite, nausea, vomiting, diarrhea.
Other: hyperuricemia, photosensitivity, rarely can develop gouty arthritis, arthralgia, sideroblastic anemia, hypersensitivity reactions.
In case of overdose occur nausea, vomiting, abdominal pain, jaundice, increased activity of “liver” enzymes, acute pulmonary edema, impaired consciousness, coma, convulsions, respiratory failure, hyperglycemia, metabolic ketoacidosis.
Treatment: gastric lavage with the introduction into the activated charcoal, forced diuresis, hemodialysis, general measures to maintain vital body functions.
- Hypersensitivity to the drug;
- bronchial asthma;
- psoriasis clenbuterol cycle;
- convulsions of various origins;
- hypertension II-III Article .;
- coronary artery disease;
- cirrhosis of the liver;
- acute hepatitis;
- renal failure;
- gastric ulcer and duodenal ulcer;
- Gout (worsening)
Ftizopiram may cause hepatotoxicity, so it should be used with caution in patients with impaired liver function in patients with chronic alcoholism, as well as in patients with malnutrition.
During treatment, patients should refrain from drinking alcohol.
When long-term therapy, and in patients with impaired liver function is recommended to regularly monitor blood count and liver function tests.
For the prevention and clenbuterol cycle treatment of peripheral neuropathy, which can develop on the background of isoniazid therapy is recommended supplementation of pyridoxine .
In some cases, particularly in patients with a history of gout attacks, it is recommended to periodically monitor the level of uric acid in the plasma. In the appointment of pyrazinamide in patients with aplastic anemia should take into account the effect of the drug on blood clotting time.
During pregnancy prescribed only under strict indications. Isoniazid and pyrazinamide are excreted in breast milk, therefore the treatment Ftizopiramom must stop breastfeeding. When receiving isoniazid in high doses (10 mg / kg or more) may develop adverse reactions in the nervous system, such as peripheral neuropathy.
Isoniazid slows the metabolism of some drugs, including phenytoin, carbamazepine, sodium valproate. When concomitant administration with isoniazid dose of these drugs is recommended reduced. Avoid concurrent use of disulfiram and isoniazid, as this can lead to mental disorders. The mechanism of this interaction is not installed.
Isoniazid increases the serum concentrations of carbamazepine and phenytoin and reduces the concentration of ketoconazole.
Pyrazinamide can clenbuterol cycle increase the concentration of uric acid in the blood serum and reduce the effectiveness of drugs for the treatment of gout, such as allopurinol, colchicine, sulfinpyrazone (you may need to increase the dose protivopodagricakih funds). While the use of pyrazinamide may decrease the plasma concentration and efficacy of cyclosporine.