liquid clenbuterol

Inhalation absorbed from the alveoli into the blood flow lumen, fast equilibration concentration occurs in the alveoli and blood. Distributed to bodies with good vascularization (brain, heart, liver), muscle, adipose tissue. Speeding histo-hematic barriers, including the blood-brain and placental. After the cessation of intake of reduction of its plasma concentration is exponential. Displays with light – 80% in an unmodified form; kidney – 20% of active metabolites.

Indications for use :
inhalation general anesthesia for large liquid clenbuterol and small surgical procedures, diagnostic procedures for different categories of patients (including those with chronic obstructive pulmonary disease, asthma and diabetes).

 

Dosage and administration:

Suitable for any type of inhalation anesthesia. Proper dosage is achieved by calibrating an evaporator arranged outside the closed circulation system (to prevent overdosing).

Introduction to the anesthetic halothane begin to feed in a concentration , then gradually increase the concentration of vapor in a mixture of halothane to about 2.4. %. Regular maintenance of the concentration -0,5-2. %. Blood concentration of 7-12 vol. % Corresponds to general anesthesia surgical step. The minimum alveolar concentration  for adults with a mixture of oxygen . % With a mixture of nitrous oxide – about 0.3. %. MAC halothane when mixed with oxygen for children up to 6 months. – About 1.08. %; -0.92 to about 10 years. %; for persons over 70 years of -0.64. %. Premedication with morphine affects .

 

Side effect:

After waking up may be headache, tremor liquid clenbuterol; increased intracranial pressure.

Since the cardiovascular system: hypotension, bradycardia, heart rhythm disorders.

From the digestive system: abnormal liver function until the development of jaundice, hepatitis, liver necrosis, especially after repeated administration; possible nausea upon awakening.

Other: in some cases may develop malignant hyperthermia.

Contraindications :
Hypersensitivity, jaundice, malignant hyperthermia (a history of the background of halothane), liver disease, cranial hypertension, the need for local administration of epinephrine in the operative field (risk of arrhythmias); pheochromocytoma, hyperthyroidism, giperkateholaminemii, hepatic failure, hypotension, arrhythmia, myasthenia gravis, the use of halothane general anesthesia for less than 3 months ago, pregnancy (1 trimester), childbirth and the early postnatal period.

Precautions receiving cardiac glycosides.

Interaction with other drugs:
Sympathomimetics increase the risk of arrhythmias. It enhances the effect of non-depolarizing action miorelaksanov, antihypertensives, bradycardia under the influence of drugs digitalis and cholinesterase inhibitors (neostigmine) reduces the effect of uterotoniziruyuschih funds. Morphine and phenothiazines enhance depressor effect on the liquid clenbuterol.

It increases the risk of liver disease on the background of phenytoin. Aminoglycosides, lincomycin and polymyxin deepen neuromuscular blockade (can cause apnea). Ketamine increases the half-life, methyldopa, nitrous oxide, morphine and fenotiaziaziny-effect of general anesthesia. The likelihood of developing malignant hyperthermia increases suxamethonium, arrhythmias – ksatin.

 

Overdose:

Symptoms: bradycardia, arrhythmia, hypotension, hyperthermal crisis, respiratory depression. Treatment: mechanical ventilation with pure oxygen, symptomatic therapy.

 

Special instructions:

Do not store in the evaporators; before the new use ephedrine of the evaporator to be cleaned from the remnants of halothane and its degradation products. Thymol (used for stabilization) does not evaporate remains in the evaporator, turning the solution a yellowish color, it is readily soluble, is removed by using ether. Levodopa should be abolished for 6-8 hours prior to liquid clenbuterol the start of general anesthesia. Patients with chronic alcoholism anesthesia high doses required.

 

clenbuterol results

Glucocorticosteroids for outdoor use; It has a local anti-inflammatory, anti-allergic, anti-edema and anti-proliferative effect. Skin contact occurs warning boundary clusters of neutrophils, resulting in reduced exudation, cytokine production, inhibition of macrophage migration, leading ultimately to a reduction in the infiltration and granulation processes.  Triamcinolone rapidly distributed in the body tissues.The main metabolite of triamcinolone . Is output through the intestine and kidneys, in equal proportions. Triamcinolone half-life of about 5 hours, plasma half-life of 18-36 hours tissues.

Indications
Skin clenbuterol results diseases responsive to glucocorticosteroids: acute and chronic eczema, atopic dermatitis, contact dermatitis, lichen planus, psoriasis, exfoliative erythroderma, Leiner’s disease, otitis externa, is not complicated by infection, insect bites.

Contraindications
: Hypersensitivity to any component of the drug, viral, bacterial (including tuberculosis) and fungal infections of the skin, trophic shin ulcers, acne rosacea, acne vulgaris, perioral dermatitis, diaper rash, children up to 2 years. Do not apply to wounds. Precautions: Pregnancy.

Pregnancy and lactation
Application ftorokort in pregnant women is allowed in cases where the potential benefit to the mother prevails over the possible risk to the fetus.
It is not known whether the drug passes into breast milk penetrates, so lactation is necessary to abandon breastfeeding.

Dosage and administration:
Outwardly.
The drug is applied thinly to the affected areas of skin 2-3 times a day (maximum daily dose of 15 g). Perhaps the use of occlusive dressings, with a maximum amount of ointment should not exceed ’10
course of treatment – usually 5-10 days, when the persistent current – up to 25 days is not recommended to use more than 4 weeks.

Side effects
Side effects when clenbuterol results applied externally occur rarely and are reversible. Burning, itching, irritation, dryness, folliculitis, hypertrichosis, akneiformnaya rash, hypopigmentation, perioral dermatitis, allergic or contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria.

Overdose
Symptoms: systemic .
Treatment: symptomatic.

Interaction with other medicinal products
For external use corticosteroids interaction with other drugs is unknown.

Cautions
If you have side effects ftorokort discontinue use of the drug.
As with other local glucocorticosteroids ftorokort drug can not be applied to the skin around the eyes and on the wound surface. In the application of occlusive dressings and used on large surfaces of the body possible systemic effects of the drug – in such cases requires increased caution, especially in the treatment of children.
If the disease is complicated by the development of secondary bacterial or fungal infection to drug therapy ftorokort need to add a specific clenbuterol results anti-bacterial or anti-fungal agent.
with extreme caution should be used drug in the skin.
use in children should proceed with caution. Keep in mind that young children skin folds and the diaper may have an effect similar to the effect of occlusive dressings, and increase systemic drug resorption.Furthermore, children can have a greater degree of systemic resorption due to the relation between the surface of the skin and body weight, as well as due to lack of maturity of the skin.
The duration of treatment in children should not exceed 5 days. Prolonged use of the drug should be under the supervision of a physician.
The use of occlusive dressings are not recommended for children.

Effects on ability to drive vehicles and work with the technique of
preparation does not affect the ability required for driving or using machinery.

clen cycle

When administered ftorafur rapidly absorbed from the gastrointestinal tract  and found in the blood of at least 24 hours after a single administration.
The maximum drug concentration in the blood is achieved within 4-6 hours after ingestion. Bioavailability is almost complete. It has high lipophilicity , while remaining water-soluble compound. High lipophilicity ensures rapid passage through biological membranes, the distribution in the body and penetrate the blood-brain barrier.
It is metabolized in the liver to produce metabolites, among which the central place is occupied by a pharmacologically active 5-fluorouracil. Bioactivation clen cycle is carried out not only in the liver, but may be of a local character and in tumor tissues contain high cytosolic hydrolytic enzymes.

INDICATIONS
Cancer of the colon and rectum, stomach, breast; atopic dermatitis, cutaneous lymphoma.

CONTRAINDICATIONS
Hypersensitivity to the drug. End-stage disease, acute profuse bleeding, severe liver and / or kidney disease, leukopenia , thrombocytopenia and anemia , pregnancy and lactation.

WITH CARE
Patients with impaired functions of blood, liver and kidneys, glucose metabolism, gastric ulcer and duodenal ulcer, a tendency to bleeding, infections.
Is not clear for kids safety of the drug.

DOSAGE AND ADMINISTRATION
inside. Ftorafura daily dose clen cycle in 2.4 reception but not more than 2 g / day. Heading dose – 30-40, the interval between courses of 4 weeks.
Ftorafura dose may be reduced in elderly patients and at a late stage of the disease.

Side effect From hemopoiesis system : a leukopenia, thrombocytopenia, anemia. On the part of the digestive system : nausea, vomiting, anorexia, abdominal pain, diarrhea; rarely – stomatitis, pharyngitis, esophagitis, ulceration of the gastrointestinal mucosa, bleeding from the gastrointestinal tract, liver dysfunction, acute hepatitis, acute pancreatitis. From the nervous system : dizziness, confusion, drowsiness, ataxia, euphoria. On the part of the cardiovascular system : false angina, angina pectoris, myocardial ischemia, myocardial infarction. On the part of the organs of vision : diplopia, lacrimation, fibrosis of the lacrimal ducts. On the part of the skin and skin appendages : alopecia, skin disorder regeneration nails. Others : allergic reactions (including anaphylactic shock ), renal failure, dehydration, leykoentsefalita symptoms, interstitial pneumonia, loss of sense of smell.

 

Overdose Symptoms :. Increase in toxic effects on the gastrointestinal tract, central nervous system and inhibition of hematopoiesis Treatment : control hematopoiesis function for at least 4 weeks, if necessary spend symptomatic therapy. The specific antidote to tegafur are not known.

 

Interaction with other drugs
With simultaneous application clen cycle ftorafura and phenytoin may increase the action of the latter.
The drug increases the efficacy of other chemotherapeutic agents and radiation therapy (also enhanced and side effects).
Inhibitors of microsomal oxidation in the liver increases the toxicity.

Cautions
In appointing ftorafura should pay special attention to patients with impaired function of blood, liver and kidneys, glucose metabolism, gastric ulcer and duodenal ulcer, a tendency to bleeding, infections.
Regularly should monitor blood picture, liver function and kidney. Prolonged use of the drug is enhanced its side effects.
It will be appreciated that the drug inhibits the reproductive function of the patient. Children safety of the drug is not clear.
Dizziness, nausea and vomiting decrease at a daily dose fractionation. With the development of serious side effects, you must discontinue use of the drug.