buy clenbuterol

Symptoms of overdose include nausea, vomiting, abdominal pain, jaundice, increased liver enzymes, acute pulmonary edema, impaired consciousness, coma, convulsions, respiratory failure, hyperglycemia, metabolic ketoacidosis.

Treatment: gastric lavage with the introduction into the activated charcoal, forced diuresis, hemodialysis, common measures to support vital functions.

Contraindications

  • Hypersensitivity buy clenbuterol to the drug;
  • bronchial asthma;
  • psoriasis;
  • convulsions of various origins;
  • epilepsy;
  • hypertension II-III Article .;
  • coronary artery disease;
  • cirrhosis of the liver;
  • acute hepatitis;
  • renal failure;
  • optic neuritis;
  • diabetic retinopathy;
  • cataract;
  • myxedema;
  • pregnancy

Drug interactions

Isoniazid slows the metabolism of some drugs, including phenytoin, carbamazepine, sodium valproate. When concomitant administration with isoniazid dose of these drugs is recommended reduced. Avoid concurrent use of disulfiram and isoniazid, as this can lead to mental disorders. The mechanism of this interaction is not installed. Isoniazid increases the serum concentrations of carbamazepine and phenytoin and reduces the concentration of ketoconazole. Ethambutol. Buy clenbuterol of ethambutol and drugs with neurotoxic effects may increase the likelihood of optic nerve damage and peripheral neuritis.

special instructions

Ftizoetam may cause hepatotoxicity, so it should be used with caution in patients with impaired liver function in patients with chronic alcoholism, as well as in patients with malnutrition.

During treatment, patients should refrain from drinking alcohol. When long-term therapy, and in patients with impaired liver function is recommended to regularly monitor blood count and liver function tests.

For the prevention and treatment of peripheral neuropathy, which can develop on the background of isoniazid therapy is recommended supplementation of pyridoxine (vitamin B6).

In some cases, particularly in patients with a history of gout attacks, it is recommended to periodically monitor the level of uric acid in the plasma. Ethambutol may have a negative effect on vision (after timely cancellation is usually normal, in rare cases, normalization of vision can occur within a year or more). It is necessary to check the visual acuity of each eye separately and both eyes together. Visual acuity is checked before the start of treatment and periodically during treatment (at revealing its reduction ethambutol cancel). patients buy clenbuterol should immediately consult a doctor with any change in visual acuity. In patients with renal impairment may require dose reduction of ethambutol.

clenbuterol side effects

Isoniazid is rapidly absorbed after oral administration, but at the same time taking the drug with food its absorption and bioavailability is reduced. After a single oral administration of 300 mg the maximum plasma concentration observed after 1-2 hours Connection with the plasma protein -. 0-10%. It penetrates into various tissues and body fluids, including bone and cerebrospinal fluid. Is acetylated and hydrolyzed in the liver. Acetylation – this is the main way of isoniazid metabolism. acetylation rate depends on the individual patient. Isoniazid metabolites have no antimicrobial activity. The half – 0.5-1.6 hours  or 2-5 hours (slow acetylation). If abnormal liver function the half-life of isoniazid is prolonged. Within 24 hours, it is excreted in urine as metabolites 5-95 unaltered – up to 12% during rapid acetylation and to 27% in slow acetylation. In severe renal insufficiency clenbuterol side effects in patients with slow atsetilironaniem possible drug accumulation.

Ethambutol: Well absorbed from the gastrointestinal tract. Bioavailability is 75-80%. Relationship to plasma proteins – 20-30%. After a single oral dose of ethambutol 25 mg / kg body weight of the maximum plasma concentration observed after 2-4 h. It penetrates into various tissues and body fluids other than spinal, ascitic and pleural fluids. Occupational are greatest in the lungs, kidneys, urine and saliva. It passes through the intact BBB. When tuberculous meningitis 10-50% of the drug penetrates through the pia mater. Treated biotransformation in the liver; to 15% of the drug is converted into inactive metabolites. Ethambutol is excreted through the kidneys (80%) and gastrointestinal (20%). half-life is 4.3 hours, renal insufficiency, it increases up to 8 hours.

Indications

All forms of tuberculosis, and the localization (treatment, including outpatient basis), chemoprophylaxis, preventive treatment).

dosage

Inside, after eating, once a day every day during the period of intensive treatment (3-4 months), and then – in a day. Total course clenbuterol side effects for each patient is individual and depends on the nature of the disease, treatment effectiveness and tolerability.

Side effect

Isoniazid

Liver: possible violation of liver function, especially in patients with malnutrition or previous liver disease, as well as in the elderly. It is recommended to monitor the ALT and ACT levels in plasma and monthly to evaluate liver function. Isoniazid should be lifted only in those cases where the transaminase levels to more than 3 times the upper limit of normal, as is often noted asymptomatic transient increase in liver enzymes, which does not require discontinuation. With the development of acute or chronic hepatitis Isoniazid should be abolished, in the latter case it is impossible to resume therapy with isoniazid. Drinking alcohol during therapy with isoniazid can increase the risk of hepatitis.

From the gastrointestinal tract: nausea, vomiting, abdominal pain, diarrhea, exacerbation of peptic ulcer.

On the part of the central and peripheral nervous system: sometimes may develop peripheral neuropathy, particularly in elderly patients, pregnant women, patients with malnutrition, diabetic patients, and in patients with chronic liver disease, including alcoholic etiology. For the prevention of peripheral neuropathy it is recommended to take pyridoxine.

Other: allergic reactions, gynaecomastia, menorrhagia.

Etambutol

On the part of the central and peripheral nervous system: possible decrease in visual acuity, which is due to optic neuritis of the optic nerve (the probability and frequency of side effects depend on the dose of ethambutol and its duration of application), very rarely – peripheral neuritis.

From the gastrointestinal clenbuterol side effects tract: discomfort, abdominal pain, loss of appetite, nausea, vomiting.

Allergic reactions: cyp, urticaria, pruritus.

clenbuterol cycle

Liver: the liver from the reaction can vary from asymptomatic dysfunction of liver cells, detectable only by laboratory methods to severe liver dysfunction, manifested by jaundice. These side effects usually do not occur when receiving pyrazinamide in doses not to exceed 25 mg / kg per day; the addition of pyrazinamide to isoniazid does not lead to an increase in the overall frequency of liver toxicity.

From the gastrointestinal tract: may clenbuterol cycle experience decreased appetite, nausea, vomiting, diarrhea.

Other: hyperuricemia, photosensitivity, rarely can develop gouty arthritis, arthralgia, sideroblastic anemia, hypersensitivity reactions.

In case of overdose occur nausea, vomiting, abdominal pain, jaundice, increased activity of “liver” enzymes, acute pulmonary edema, impaired consciousness, coma, convulsions, respiratory failure, hyperglycemia, metabolic ketoacidosis.

Treatment: gastric lavage with the introduction into the activated charcoal, forced diuresis, hemodialysis, general measures to maintain vital body functions.

Contraindications

  • Hypersensitivity to the drug;
  • bronchial asthma;
  • psoriasis clenbuterol cycle;
  • convulsions of various origins;
  • epilepsy;
  • hypertension II-III Article .;
  • coronary artery disease;
  • cirrhosis of the liver;
  • acute hepatitis;
  • renal failure;
  • gastric ulcer and duodenal ulcer;
  • myxedema;
  • Gout (worsening)

special instructions

Ftizopiram may cause hepatotoxicity, so it should be used with caution in patients with impaired liver function in patients with chronic alcoholism, as well as in patients with malnutrition.

During treatment, patients should refrain from drinking alcohol.

When long-term therapy, and in patients with impaired liver function is recommended to regularly monitor blood count and liver function tests.

For the prevention and clenbuterol cycle treatment of peripheral neuropathy, which can develop on the background of isoniazid therapy is recommended supplementation of pyridoxine .

In some cases, particularly in patients with a history of gout attacks, it is recommended to periodically monitor the level of uric acid in the plasma. In the appointment of pyrazinamide in patients with aplastic anemia should take into account the effect of the drug on blood clotting time.

During pregnancy prescribed only under strict indications. Isoniazid and pyrazinamide are excreted in breast milk, therefore the treatment Ftizopiramom must stop breastfeeding. When receiving isoniazid in high doses (10 mg / kg or more) may develop adverse reactions in the nervous system, such as peripheral neuropathy.

Drug interactions

Isoniazid slows the metabolism of some drugs, including phenytoin, carbamazepine, sodium valproate. When concomitant administration with isoniazid dose of these drugs is recommended reduced. Avoid concurrent use of disulfiram and isoniazid, as this can lead to mental disorders. The mechanism of this interaction is not installed.

Isoniazid increases the serum concentrations of carbamazepine and phenytoin and reduces the concentration of ketoconazole.

Pyrazinamide can clenbuterol cycle increase the concentration of uric acid in the blood serum and reduce the effectiveness of drugs for the treatment of gout, such as allopurinol, colchicine, sulfinpyrazone (you may need to increase the dose protivopodagricakih funds). While the use of pyrazinamide may decrease the plasma concentration and efficacy of cyclosporine.